Neurxtem Receives NIH SBIR Substance Use Disorder and the Opioid Crisis Funding Award (2020)

NIH HEAL Initiative Research Plan


The research plan outlines the initiative’s goals, research priorities based on urgent unmet needs, areas of scientific opportunity, and concrete strategies for rapid and long-lasting solutions to the opioid crisis.

Current state of the art technologies for CNS disease mechanism studies and drug discovery include human cell lines to rodent models. These models poorly reflect the complex structure of the human brain and are failing in their predictive capacity in translational medicine applications. The proposed proprietary induced pluripotent stem cell-derived human neural organoid model system that yields clinically corroborated preliminary results for a drug of abuse is expected to fill this crucial gap for future translational neuroscience goals to understand and treat substance and opioid use disorders.